Release date 2024.9.2
In August 2024, the latest research on weight changes caused by antidepressants was reported 1).
The study compared weight changes for the following eight drugs, using sertraline as the baseline:
- Citalopram（Celexa）
- Escitalopram（Lexapro）
- Fluoxetine（Prozac）
- Paroxetine（Paxil）
- Bupropion（Wellbutrin）
- Duloxetine（Cymbalta）
- Venlafaxine（Effexor）
The results of weight changes after six months of starting the medication were as follows (Figure 1):
- Citalopram：+0.12kg
- Escitalopram：+0.41kg
- Fluoxetine：-0.07kg
- Paroxetine：+0.37kg
- Bupropion：-0.22kg
- Duloxetine：+0.34kg
- Venlafaxine：+0.17kg
（Fig 1）Weight changes with each antidepressant compared to sertraline（after 6 months）
Patients taking escitalopram, paroxetine, and duloxetine experienced a weight gain of 0.3 to 0.4 kg more than those taking sertraline. Additionally, the likelihood of gaining at least 5% more weight from their original weight was found to be 10% to 15% higher.
Based on these results, the authors suggest that these differences could be considered in decisions between physicians and patients, especially when obesity is associated with depression.
References
- 1）Petimar et al.: Medication-Induced Weight Change Across Common Antidepressant Treatments: A Target Trial Emulation Study. Ann Intern Med, 177: 993-1003, 2024.
Column list
- Characteristics, Mechanism of Action, and Side Effects of Zuranolone
- Characteristics, Mechanism of Action, and Side Effects of Auvelity
- Characteristics, Mechanism of Action, and Side Effects of Esketamine
- Latest Comparison of Weight Changes Due to Antidepressants
- Comparison of the Efficacy of Long-Acting Injectable Antipsychotics in Acute Schizophrenia: Latest Report
- Comparison of Efficacy and Tolerability of Drug Treatments in Acute Manic Episodes of Bipolar Disorder: Latest Report
- 頭が働かない
- 寝つきが悪い
- やる気が起きない
- 不安で落ち着かない
- 朝寝坊が多い
- 人の視線が気になる
- 職場に行くと体調が悪くなる
- 電車やバスに乗ると息苦しくなる
- うつ病
- 強迫性障害
- 頭痛
- 睡眠障害
- 社会不安障害
- PMDD（月経前不快気分障害）
- パニック障害
- 適応障害
- 過敏性腸症候群
- 心身症
- 心的外傷後ストレス障害
- 身体表現性障害
- 発達障害
- ADHD（注意欠如・多動症）
- 気象病・天気痛
- テクノストレス
- バーンアウト症候群
- ペットロス（症候群）
- 更年期障害
- 自律神経失調症
